The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review.

ABSTRACT:

Background

The genetic alterations of papillary thyroid carcinoma (PTC) have been reported to change over the past few decades. We performed this systematic review to further examine the trends and modifications of patient demographic, clinicopathological features and molecular profiles of PTC over time.

Methods

A literature search was performed within six electronic databases to identify relevant articles. The inclusion criteria were published studies investigating BRAF mutations, RET/PTC rearrangements or RAS mutations in PTCs or classical PTCs. Two teams of reviewers independently screened titles and abstracts of all articles. Full texts of potential articles were read and extracted data were listed and stratified into an excel file according to country, city, institution

SUBMITTER: Vuong HG 

PROVIDER: S-EPMC5354688 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature