Ontology highlight
ABSTRACT:
SUBMITTER: Choi SA
PROVIDER: S-EPMC5354719 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Oncotarget 20170201 6
There have been extensive efforts to improve the outcome of glioblastoma, but the prognosis of this disease has not been significantly altered to date. Histone deacetylase inhibitors (HDACIs) have been evaluated as promising anti-cancer drugs and regulate cell growth, cell cycle arrest and apoptosis in glioblastoma. Here, we demonstrated the therapeutic efficacy of a novel pan-HDACI, 7-ureido-N-hydroxyheptanamide derivative (CKD5), compared with traditional pan-HDACIs, such as suberoylanilide hy ...[more]