Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner.

ABSTRACT: The androgen receptor (AR) is a member of the nuclear receptor superfamily of transcription factors and is central to prostate cancer (PCa) progression. Ligand-activated AR engages androgen response elements (AREs) at androgen-responsive genes to drive the expression of gene batteries involved in cell proliferation and cell fate. Understanding the transcriptional targets of the AR has become critical in apprehending the mechanisms driving treatment-resistant stages of PCa. Although AR transcription regulation has been extensively studied, the signaling networks downstream of AR are incompletely described. Semaphorin 3C (SEMA3C) is a secreted signaling protein with roles in nervous system and cardiac development but can also drive cellular growth and invasive characteristics in multiple can

SUBMITTER: Tam KJ 

PROVIDER: S-EPMC5354758 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature