Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis.

ABSTRACT: Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The im

SUBMITTER: Ivanov AV 

PROVIDER: S-EPMC5354803 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature