The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition.
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ABSTRACT:
SUBMITTER: Onofrillo C
PROVIDER: S-EPMC5354829 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition.
Onofrillo Carmine C Galbiati Alice A Montanaro Lorenzo L Derenzini Massimo M
Oncotarget 20170101 3
Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA. ...[more]
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