Association between the HOTAIR polymorphisms and cancer risk: an updated meta-analysis.

ABSTRACT:

Purpose

LncRNA HOTAIR plays an important role in many cancer. Several studies have shown that some HOTAIR SNPs might be associated with tumor risk in case-control studies, but the results are inconsistent and inconclusive. Therefore, it is necessary to better evaluate association between the HOTAIR SNPs and the risk of cancer.

Results

rs920778, rs7958904 and rs874945 but not rs4759314 and rs1899663 loci were significantly related to cancer risk, among of which rs920778 and rs874945 increased and rs7958904 decreased cancer risk, respectively. Moreover, rs920778 is significantly susceptible in both Asian population and digestive cancer risks.

Materials and methods

Data were collected from PubMed, Embase and Web of Science. A total of 11 case-control studies were selecte

SUBMITTER: Zhang ZX 

PROVIDER: S-EPMC5354846 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature