LHBs can elevate the expression of MDR1 through HIF-1α in patients with CHB infection: a comparative proteomic study.

ABSTRACT:

Background and aims

Hepatitis B virus (HBV) infection is a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). To gain a better understanding of the pathogenesis of HBV infection, this study aimed to investigate the differentially expressed proteins (DEPs) in liver tissues from patients with chronic hepatitis B (CHB) infection.

Results

Seventy-one DEPs were identified. Overexpression of multi-drug resistance protein 1 (MDR1) was validated by RT-qPCR and western blot analyses. Moreover, its expression was increased at both the mRNA and protein levels in response to overexpression of HBV large surface protein (LHBs). Furthermore, screening of transcription factors suggested the possible involvement of hypoxia-inducible factor 1α (HIF-1α) in the interactio

SUBMITTER: Li S 

PROVIDER: S-EPMC5354853 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature