IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis.

ABSTRACT:

Objectives

Since a genome-wide association study revealed that Interleukin-23 receptor (IL-23R) gene is a candidate gene for Ulcerative Colitis (UC), many studies have investigated the association between the IL-23R polymorphisms and UC. However, the results were controversial. The aim of the study was to determine whether the IL-23R polymorphisms confer susceptibility to UC.

Methods

A systematic literature search was carried out to identify all potentially relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association.

Results

A total of 33 studies in 32 articles, including 10,527 UC cases and 15,142 healthy controls, were finally involved in the meta-analysis. Overall, a significant association was fo

SUBMITTER: Peng LL 

PROVIDER: S-EPMC5354875 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature