Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients.

ABSTRACT:

Purpose

Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via phosphorylation. Protein kinase C (PKC) is one kinase that can mediate AR phosphorylation. This study aimed to establish if AR phosphorylation by PKC is of prognostic significance.

Methods

Immunohistochemistry for AR, AR phosphorylated at Ser-81 (pARS81), AR phosphorylated at Ser-578 (pARS578), PKC and phosphorylated PKC (pPKC) was performed on 90 hormone-naïve prostate cancer specimens. Protein expression was quantified using the weighted histoscore method and examined with regard to clinico-pathological factors and outcome measures; time to biochemical relapse, survival from biochemical relapse and disease-specific survival.

Results

Nuclear PKC expression strongly corre

SUBMITTER: Patek S 

PROVIDER: S-EPMC5354877 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature