Genomic differences between black and white patients implicate a distinct immune response to papillary renal cell carcinoma.

ABSTRACT: Significant disparities in survival, incidence and possibly response to current therapies exist between black and white patients with renal cell carcinoma (RCC). Recent genomic evidence to account for these disparities has been reported for clear cell RCC. However, racial disparities at the genomic level for papillary RCC (pRCC) which is a genetically distinct and less responsive histologic subtype of RCC have not been reported. Using The Cancer Genome Atlas (TCGA) data, the present study assessed gene-level expression, somatic mutation and pathway differences between 58 black and 58 white patients with pRCC propensity matched on age, gender and pathologic T stage. Distinct tumor biology with differential expression patterns were observed in black vs. white patients with pRCC. Specifically

SUBMITTER: Paulucci DJ 

PROVIDER: S-EPMC5354901 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature