Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet.

ABSTRACT: Morbidly obese patients who accomplish substantial weight loss often display a long-term decline in their resting metabolism, causing even relatively restrained caloric intake to trigger a relapse to the obese state. Paradoxically, we observed that morbidly obese mice receiving chemotherapy for cancer experienced spontaneous weight reduction despite unabated ingestion of their high fat diet (HFD). This response to chemotherapy could also be achieved in morbidly obese mice without cancer. Optimally dosed methotrexate (MTX) or cyclophosphamide (CY) enabled the mice to completely and safely normalize their body weight despite continued consumption of obesogenic quantities of HFD. Weight reduction was not attributable to decreased HFD intake, enhanced energy expenditure or malabsorption. MTX o

SUBMITTER: Myers CE 

PROVIDER: S-EPMC5354920 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature