Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

ABSTRACT: Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The classification of the World Health Organization (WHO) divides the disease into cutaneous mastocytosis, systemic mastocytosis, and localized mast cell tumors. On the basis of histomorphologic criteria, clinical parameters, and organ involvement, systemic mastocytosis is further divided into indolent systemic mastocytosis and advanced systemic mastocytosis variants, including aggressive systemic mastocytosis and mast cell leukemia. The clinical impact and prognostic value of this classification has been confirmed in numerous studies, and its basic concept remains valid. However, refinements have recently been propo

SUBMITTER: Valent P 

PROVIDER: S-EPMC5354959 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature