Circulating Antioxidant Levels and Risk of Prostate Cancer by TMPRSS2:ERG.

ABSTRACT:

Background

Few studies have considered etiological differences across molecular subtypes of prostate cancer, despite potential to improve opportunities for precision prevention of a disease for which modifiable risk factors have remained elusive. Factors that lead to DNA double-strand breaks, such as oxidative stress, may promote the formation of the TMPRSS2:ERG gene fusion in prostate cancer. We tested the hypothesis that increasing levels of pre-diagnostic circulating antioxidants, which may reduce oxidative stress, are associated with lower risk of developing TMPRSS2:ERG positive prostate cancer.

Methods

We conducted a nested case-control study, including 370 cases and 2,470 controls, to evaluate associations between pre-diagnostic α- and β-carotene, α- and γ-tocopherol,

SUBMITTER: Graff RE 

PROVIDER: S-EPMC5354965 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature