The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children.

ABSTRACT: Genetic profiling is an increasingly useful tool for sub-classification of gliomas in adults and children. Specific gene mutations, structural rearrangements, DNA methylation patterns, and gene expression profiles are now recognized to define molecular subgroups of gliomas that arise in distinct anatomic locations and patient age groups, and also provide a better prediction of clinical outcomes for glioma patients compared to histologic assessment alone. Understanding the role of these distinctive genetic alterations in gliomagenesis is also important for the development of potential targeted therapeutic interventions. Mutations including K27M and G34R/V that affect critical amino acids within the N-terminal tail of the histone H3 variants, H3.3 and H3.1 (encoded by H3F3A and HIST1H3B gene

SUBMITTER: Lee J 

PROVIDER: S-EPMC5354997 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature