Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice.

ABSTRACT:

Aim

Increasing evidence demonstrates that circadian clock proteins are important regulators of physiological functions including blood pressure. An established risk factor for developing cardiovascular disease is the absence of a blood pressure dip during the inactive period. The goal of the present study was to determine the effects of a high salt diet plus mineralocorticoid on PER1-mediated blood pressure regulation in a salt-resistant, normotensive mouse model, C57BL/6J.

Methods

Blood pressure was measured using radiotelemetry. After control diet, wild-type (WT) and Per1 (KO) knockout mice were given a high salt diet (4% NaCl) and the long-acting mineralocorticoid deoxycorticosterone pivalate. Blood pressure and activity rhythms were analysed to evaluate changes over time

SUBMITTER: Solocinski K 

PROVIDER: S-EPMC5354999 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature