Galectin-1 inhibits oral-intestinal allergy syndrome.

ABSTRACT:

Background and aims

The pathogenesis of oral-intestinal allergy syndrome (OIAS) has not been well understood. Published data indicate that galectin (Gal) 1 has immune regulatory functions. This study tests a hypothesis that Gal1 inhibits oral-intestinal allergy syndrome.

Methods

Mice were sensitized to peanut extracts (PE) via the buccal mucosa with or without using Gal1 together.

Results

Upon re-exposure to specific antigen, the OIAS mice showed the systemic allergic response, the oral allergic reactions, and intestinal allergic inflammation, including increases in serum histamine, drop of the core temperature, higher levels of PE-specific IgE and interleukin (IL)-4. Increases in mast cell and eosinophil in the oral mucosa and intestinal mucosa were also observed. Th

SUBMITTER: Xie RD 

PROVIDER: S-EPMC5355090 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature