Ontology highlight
ABSTRACT:
SUBMITTER: Kraft A
PROVIDER: S-EPMC5355570 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Stem cell reports 20170216 3
Brain injuries, such as stroke or trauma, induce neural stem cells in the subventricular zone (SVZ) to a neurogenic response. Very little is known about the molecular cues that signal tissue damage, even over large distances, to the SVZ. Based on our analysis of gene expression patterns in the SVZ, 48 hr after an ischemic lesion caused by middle cerebral artery occlusion, we hypothesized that the presence of an injury might be transmitted by an astrocytic traveling calcium wave rather than by di ...[more]