BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies.

ABSTRACT: BK polyomavirus (BKV) causes frequent infections during childhood and establishes persistent infections within renal tubular cells and the uroepithelium, with minimal clinical implications. However, reactivation of BKV in immunocompromised individuals following renal or hematopoietic stem cell transplantation may cause serious complications, including BKV-associated nephropathy (BKVAN), ureteric stenosis, or hemorrhagic cystitis. Implementation of more potent immunosuppression and increased posttransplant surveillance has resulted in a higher incidence of BKVAN. Antiviral immunity plays a crucial role in controlling BKV replication, and our increasing knowledge about host-virus interactions has led to the development of improved diagnostic tools and clinical management strategies. Currentl

SUBMITTER: Ambalathingal GR 

PROVIDER: S-EPMC5355639 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature