OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation.

ABSTRACT: We describe the ability of an engineered glycosyltransferase (OleD Loki) to catalyze the N-glycosylation of tertiary-amine-containing drugs and trichostatin hydroxamate glycosyl ester formation. As such, this study highlights the first bacterial model catalyst for tertiary-amine N-glycosylation and further expands the substrate scope and synthetic potential of engineered OleDs. In addition, this work could open the door to the discovery of similar capabilities among other permissive bacterial glycosyltransferases.

SUBMITTER: Hughes RR 

PROVIDER: S-EPMC5355705 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature