A concerted two-prong approach to the in situ allosteric regulation of bifunctional catalysis.

ABSTRACT: Herein, we report the reversible in situ "on-off" allosteric regulation of hydrogen-bond-donating (HBD)-Lewis base co-catalytic activity via a concerted two-prong methodology entailing cooperative acid-base chemistry and a structurally addressable coordination complex. Specifically, a heteroligated Pt(ii) weak-link approach (WLA) tweezer complex containing both a hemilabile squaramide-piperidine-based catalytic ligand and a sodium sulfonate hydrogen-bond-accepting (HBA) ligand was synthesized. Due to the hemilabile nature of the catalyst-containing ligand, the heteroligated complex can be reversibly toggled in situ between a flexible, semi-open state and a rigid, fully closed state upon the addition of elemental ion cues. ¹H NMR spectroscopy titration studie

SUBMITTER: McGuirk CM 

PROVIDER: S-EPMC5355828 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature