Prognostication and monitoring of mesothelioma using biomarkers: a systematic review.

ABSTRACT:

Background

Radiological markers of treatment response and prognostication in malignant pleural mesothelioma have limitations due to the morphology of the disease. Serum or pleural fluid biomarkers that could act as an adjunct to radiological assessment would be of significant value. The aim of this review was to collate and summarise the literature relating to this topic.

Methods

A systematic review was performed on the databases Pubmed and EMBASE to identify relevant studies. Two independent researchers read the abstracts and used the Quality in Prognostic Studies tool to assess the quality of the evidence.

Results

Forty-five studies were identified from the current literature. Twenty studies investigated the role of serum soluble mesothelin with majority suggesting

SUBMITTER: Arnold DT 

PROVIDER: S-EPMC5355927 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature