Sex differences in the molecular signature of the developing mouse hippocampus.

ABSTRACT:

Background

A variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, major depressive disorder, dyslexia and autism, are differentially prevalent between females and males. To better understand the possible molecular basis for the sex-biased nature of neurological disorders, we used a developmental series of female and male mice at 1, 2, and 4 months of age to assess both mRNA and protein in the hippocampus with RNA-sequencing and mass-spectrometry, respectively.

Results

The transcriptomic analysis identifies 2699 genes that are differentially expressed between animals of different ages. The bulk of these differentially expressed genes are changed in both sexes at one or more ages, but a total of 198 transcripts are differentially expressed bet

SUBMITTER: Bundy JL 

PROVIDER: S-EPMC5356301 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature