Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma.

ABSTRACT:

Background

Disruptor of telomeric silencing 1-like (Dot1l), a histone methyltransferase that targets the histone H3 lysine 79 (H3K79), has been reported that its high expression is associated with various cancers, while the association between Dot1l expression and clear-cell renal cell carcinoma (ccRCC) is still unknown.

Patients and methods

We retrospectively enrolled 282 patients with ccRCC undergoing nephrectomy from a single institution between 2005 and 2007, with a median follow-up of 99 months. Dot1l expression was evaluated by immunohistochemistry in clinical specimens. We compared the clinical outcomes by Kaplan-Meier survival analyses and assessed the prognostic value of Dot1l expression. Harrell's concordance index (C-index) was used to assess the predictive accura

SUBMITTER: Qu Y 

PROVIDER: S-EPMC5356697 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature