Elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin-conducted iron egress.

ABSTRACT: Although we and other studies indicated ZNF217 expression was increased in prostate cancer (PCa), the factors mediating its misregulated expression and their oncogenic activity remain largely unexplored. Recent evidence demonstrated that ferroportin (FPN) reduction lead to decreased iron export and increased intercellular iron that consequently aggravates the oncogenic effects of iron. In the present study, ZNF217 was identified as a transcriptional repressor that inhibits FPN expression. Increased of ZNF217 expression led to decreased FPN concentration, coupled with resultant intracellular iron retention, increased iron-related cellular activities and enhanced tumor cell growth. In contrast, decreased of ZNF217 expression restrained tumor cell growth by promoting FPN-driven iron egress. M

SUBMITTER: Jiang X 

PROVIDER: S-EPMC5356707 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature