The relationship between polymorphisms of XRCC5 genes with astrocytoma prognosis in the Han Chinese population.

ABSTRACT:

Background

Gliomas are highly malignant with a poor prognosis. Studies have reported that DNA repair genes influence risk for glioma, but its relationship with prognosis is unclear. In this study, we want to explore the relationship between DNA repair genes (XRCC3, XRCC4 and XRCC5) and prognosis of astrocytoma in the Chinese Han population.

Materials and methods

160 astrocytoma cases were recruited in our study. Survival probabilities were estimated by using Kaplan-Meier analysis, and significant differences were analyzed by using the log-rank test. Cox proportional hazards models were used to analyze the associations between genotypes with astrocytoma survival. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable models. All tests were two

SUBMITTER: He X 

PROVIDER: S-EPMC5356736 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature