Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells.

ABSTRACT: CD48 (SLAMF2) is an adhesion and costimulatory molecule constitutively expressed on hematopoietic cells. Polymorphisms in CD48 have been linked to susceptibility to multiple sclerosis (MS), and altered expression of the structurally related protein CD58 (LFA-3) is associated with disease remission in MS. We examined CD48 expression and function in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We found that a subpopulation of CD4⁺ T cells highly upregulated CD48 expression during EAE and were enriched for pathogenic CD4⁺ T cells. These CD48⁺⁺CD4⁺ T cells were predominantly CD44⁺ and Ki67⁺, included producers of IL-17A, GM-CSF, and IFN-γ, and were most of the CD4⁺ T cells in the CNS. Administ

SUBMITTER: McArdel SL 

PROVIDER: S-EPMC5356934 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature