Functional Connectivity of the Pedunculopontine Nucleus and Surrounding Region in Parkinson's Disease.

ABSTRACT: Deep brain stimulation of the pedunculopontine nucleus and surrounding region (PPNR) is a novel treatment strategy for gait freezing in Parkinson's disease (PD). However, clinical results have been variable, in part because of the paucity of functional information that might help guide selection of the optimal surgical target. In this study, we use simultaneous magnetoencephalography and local field recordings from the PPNR in seven PD patients, to characterize functional connectivity with distant brain areas at rest. The PPNR was preferentially coupled to brainstem and cingulate regions in the alpha frequency (8-12 Hz) band and to the medial motor strip and neighboring areas in the beta (18-33 Hz) band. The distribution of coupling also depended on the vertical distance of the electrode f

SUBMITTER: Jha A 

PROVIDER: S-EPMC5357066 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature