Ontology highlight
ABSTRACT:
SUBMITTER: Cheung KL
PROVIDER: S-EPMC5357147 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cheung Ka Lung KL Zhang Fan F Jaganathan Anbalagan A Sharma Rajal R Zhang Qiang Q Konuma Tsuyoshi T Shen Tong T Lee June-Yong JY Ren Chunyan C Chen Chih-Hung CH Lu Geming G Olson Matthew R MR Zhang Weijia W Kaplan Mark H MH Littman Dan R DR Walsh Martin J MJ Xiong Huabao H Zeng Lei L Zhou Ming-Ming MM
Molecular cell 20170303 6
The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation. Brd2 is associated with the chromatin insulator CTCF and the cohesin complex to support cis-regulatory enhancer assembly for gene transcriptional activat ...[more]