Discordance of Somatic Mutations Between Asian and Caucasian Patient Populations with Gastric Cancer.

ABSTRACT:

Background

Differences in response to cancer treatments have been observed among racially and ethnically diverse gastric cancer (GC) patient populations. In the era of targeted therapy, mutation profiling of cancer is a crucial aspect of making therapeutic decisions. Mapping driver gene mutations for the GC patient population as a whole has significant potential to advance precision therapy.

Methods

GC patients with sequencing data (N = 473) were obtained from The Cancer Genome Atlas (TCGA; n = 295), Moffitt Cancer Center Total Cancer Care™ (TCC; n = 33), and three published studies (n = 145). In addition, relevant somatic mutation frequency data were obtained from cBioPortal, the TCC database, and an in-house analysis tool, as well as relevant publications.

Results

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SUBMITTER: Jia F 

PROVIDER: S-EPMC5357153 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature