High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial.

ABSTRACT:

Objectives

To determine the efficacy and safety of high-dose vitamin D supplementation for prevention of acute respiratory infection (ARI) in older long-term care residents.

Design

Randomized controlled trial investigating high-dose vs standard-dose vitamin D from 2010 to 2014.

Setting

Colorado long-term care facilities.

Participants

Long-term care residents aged 60 and older (n = 107).

Intervention

The high-dose group received monthly supplement of vitamin D₃ 100,000 IU, the standard-dose group received a monthly placebo (for participants taking 400-1,000 IU/d as part of usual care) or a monthly supplement of 12,000 IU of vitamin D₃ (for participants taking <400 IU/d as part of usual care).

Measurements

The primary outcome w

SUBMITTER: Ginde AA 

PROVIDER: S-EPMC5357189 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature