Radiosurgery for brainstem metastases with and without whole brain radiotherapy: clinical series and literature review.

ABSTRACT:

Objective

The objective of this study was to investigate outcomes for patients with brainstem metastases treated with stereotactic radiosurgery (SRS).

Methods

Patients with brainstem metastases treated with SRS between April 2006 and June 2012 were identified from a prospective database. Patient and treatment-related factors were recorded. Kaplan-Meier analysis was used to calculate survival and freedom from local and distant brain progression. Univariate and multivariate Cox regression was used to identify factors important for overall survival.

Results

In total, 44 patients received SRS for 48 brainstem metastases of whom 33 (75 %) also received whole brain radiotherapy (WBRT): 23 patients (52 %) WBRT prior to SRS, 6 (13.6 %) WBRT concurrently with SRS and 4 (9.0 %)

SUBMITTER: Murray L 

PROVIDER: S-EPMC5357261 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature