Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease.

ABSTRACT: Cardiomyocytes proliferate profusely during early development and for a brief period after birth in mammals. Within a month after birth, this proliferative capability is dramatically reduced in mammals unlike lower vertebrates where it persists into adult life. The zebrafish, for example, retains the ability to regenerate the apex of the heart following resection by a mechanism predominantly driven by cardiomyocyte proliferation. Differences in proliferative capacity of cardiomyocytes in adulthood between mammals and lower vertebrates are closely liked to ontogenetic or phylogenetic factors. Elucidation of these factors has the potential to provide enormous benefits if they lead to the development of therapeutic strategies that facilitate cardiomyocyte proliferation. In this review, we hig

SUBMITTER: Matrone G 

PROVIDER: S-EPMC5357290 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature