Maternal BCG scar is associated with increased infant proinflammatory immune responses.

ABSTRACT:

Introduction

Prenatal exposures such as infections and immunisation may influence infant responses. We had an opportunity to undertake an analysis of innate responses in infants within the context of a study investigating the effects of maternal mycobacterial exposures and infection on BCG vaccine-induced responses in Ugandan infants.

Material and methods

Maternal and cord blood samples from 29 mother-infant pairs were stimulated with innate stimuli for 24h and cytokines and chemokines in supernatants were measured using the Luminex® assay. The associations between maternal latent Mycobacterium tuberculosis infection (LTBI), maternal BCG scar (adjusted for each other's effect) and infant responses were examined using linear regression. Principal Component Analysis (PCA) was

SUBMITTER: Mawa PA 

PROVIDER: S-EPMC5357573 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature