Splice form-dependent regulation of axonal arbor complexity by FMRP.

ABSTRACT: The autism-related protein Fragile X mental retardation protein (FMRP) is an RNA binding protein that plays important roles during both nervous system development and experience dependent plasticity. Alternative splicing of the Fmr1 locus gives rise to 12 different FMRP splice forms that differ in the functional and regulatory domains they contain as well as in their expression profile among brain regions and across development. Complete loss of FMRP leads to morphological and functional changes in neurons, including an increase in the size and complexity of the axonal arbor. To investigate the relative contribution of the FMRP splice forms to the regulation of axon morphology, we overexpressed individual splice forms in cultured wild type rat cortical neurons. FMRP overexpression led to a

SUBMITTER: Zimmer SE 

PROVIDER: S-EPMC5357598 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature