Dataset Information

Defining the Roles of the Cation Diffusion Facilitators in Fe²⁺/Zn²⁺ Homeostasis and Establishment of Their Participation in Virulence in Pseudomonas aeruginosa.

ABSTRACT: Transporters of the cation diffusion facilitator (CDF) family form dimers that export transition metals from the cytosol. The opportunistic pathogen Pseudomonas aeruginosa encodes three homologous CDF genes, czcD (PA0397), aitP (PA1297), and yiiP (PA3963). The three proteins are required for virulence in a plant host model. Disruption of the aitP gene leads to higher Fe²⁺ and Co²⁺ sensitivity together with an intracellular accumulation of these ions and to a decreased survival in presence of H₂O₂. Strains lacking czcD and yiiP showed low Zn²⁺ sensitivity. However, in iron-rich media and in the presence of Zn²⁺ these strains secreted higher levels of the iron chelator pyoverdin

SUBMITTER: Salusso A

PROVIDER: S-EPMC5357649 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Dataset Information

Defining the Roles of the Cation Diffusion Facilitators in Fe²⁺/Zn²⁺ Homeostasis and Establishment of Their Participation in Virulence in Pseudomonas aeruginosa.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Defining the Roles of the Cation Diffusion Facilitators in Fe2+/Zn2+ Homeostasis and Establishment of Their Participation in Virulence in Pseudomonas aeruginosa.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Defining the Roles of the Cation Diffusion Facilitators in Fe²⁺/Zn²⁺ Homeostasis and Establishment of Their Participation in Virulence in Pseudomonas aeruginosa.