Alzheimer's Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid.

ABSTRACT: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that slowly destroys memory and thinking skills, resulting in behavioral changes. It is estimated that nearly 36 million are affected globally with numbers reaching 115 million by 2050. AD can only be definitively diagnosed at autopsy since its manifestations of senile plaques and neurofibrillary tangles throughout the brain cannot yet be fully captured with current imaging technologies. Current AD therapeutics have also been suboptimal. Besides identifying markers that distinguish AD from controls, there has been a recent drive to identify better biomarkers that can predict the rates of cognitive decline and neocortical amyloid burden in those who exhibit preclinical, prodromal, or clinical AD. This review covers biomark

SUBMITTER: Huynh RA 

PROVIDER: S-EPMC5357660 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature