Comprehensive genomic profiling (CGP) of ovarian clear cell carcinomas (OCCC) identifies clinically relevant genomic alterations (CRGA) and targeted therapy options.

ABSTRACT: •MTOR pathway genes are often mutated in ovarian clear cell carcinomas (OCCC).•11.2% of OCCC have targetable alterations only in the mTOR pathway.•MTOR pathway mutations in OCCC can underlie robust, lasting responses to everolimus.

SUBMITTER: Elvin JA 

PROVIDER: S-EPMC5357688 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature