Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial.

ABSTRACT:

Background

Accurate monitoring of changes in dietary patterns in response to food policy implementation is challenging. Metabolic profiling allows simultaneous measurement of hundreds of metabolites in urine, the concentrations of which can be affected by food intake. We hypothesised that metabolic profiles of urine samples developed under controlled feeding conditions reflect dietary intake and can be used to model and classify dietary patterns of free-living populations.

Methods

In this randomised, controlled, crossover trial, we recruited healthy volunteers (aged 21-65 years, BMI 20-35 kg/m²) from a database of a clinical research unit in the UK. We developed four dietary interventions with a stepwise variance in concordance with the WHO healthy eating guidelin

SUBMITTER: Garcia-Perez I 

PROVIDER: S-EPMC5357736 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature