Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface.

ABSTRACT: Two major monocyte subsets, CD14⁺CD16^- (classical) and CD14^+/dimCD16⁺ (nonclassical/intermediate), have been described. Each has different functions ascribed in its interactions with vascular endothelial cells (EC), including migration and promoting inflammation. Although monocyte subpopulations have been studied in isolated systems, their influence on EC and on the course of inflammation has been ignored. In this study, using unstimulated or cytokine-activated EC, we observed significant differences in the recruitment, migration, and reverse migration of human monocyte subsets. Associated with this, and based on their patterns of cytokine secretion, there was a difference in their capacity to activate EC and support the secondary recruitment of

SUBMITTER: Chimen M 

PROVIDER: S-EPMC5357784 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature