Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening.

ABSTRACT: The natural product mangiferin (compound 7) has been identified as a potential glucokinase activator by structure-based virtual ligand screening. It was proved by enzyme activation experiment and cell-based assays in vitro, with potency in micromolar range. Meanwhile, this compound showed good antihyperglycemic activity in db/db mice without obvious side effects such as excessive hypoglycaemia.

SUBMITTER: Min Q 

PROVIDER: S-EPMC5357792 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature