Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents.

ABSTRACT: Cyclooxygenase-2 (COX-2) is one of the important mediators of inflammation in response to viral infection, and it contributes to viral replication, for example, cytomegalovirus or hepatitis C virus replication. The role of COX-2 in dengue virus (DENV) replication remains unclear. In the present study, we observed an increased level of COX-2 in patients with dengue fever compared with healthy donors. Consistent with the clinical data, an elevated level of COX-2 expression was also observed in DENV-infected ICR suckling mice. Using cell-based experiments, we revealed that DENV-2 infection significantly induced COX-2 expression and prostaglandin E₂ (PGE₂) production in human hepatoma Huh-7 cells. The exogenous expression of COX-2 or PGE₂ treatment dose-depende

SUBMITTER: Lin CK 

PROVIDER: S-EPMC5357798 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature