A Novel Method for Screening Adenosine Receptor Specific Agonists for Use in Adenosine Drug Development.

ABSTRACT: Agonists that target the A₁, A_2A, A_2B and A₃ adenosine receptors have potential to be potent treatment options for a number of diseases, including autoimmune diseases, cardiovascular disease and cancer. Because each of these adenosine receptors plays a distinct role throughout the body, obtaining highly specific receptor agonists is essential. Of these receptors, the adenosine A_2AR and A_2BR share many sequence and structural similarities but highly differ in their responses to inflammatory stimuli. Our laboratory, using a combination of specially developed cell lines and calcium release analysis hardware, has created a new and faster method for determining specificity of synthetic adenosine agonist compounds for the A_2A

SUBMITTER: Jones KR 

PROVIDER: S-EPMC5357845 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature