Ontology highlight
ABSTRACT:
SUBMITTER: Yeh P
PROVIDER: S-EPMC5357854 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature communications 20170317
Several novel therapeutics are poised to change the natural history of chronic lymphocytic leukaemia (CLL) and the increasing use of these therapies has highlighted limitations of traditional disease monitoring methods. Here we demonstrate that circulating tumour DNA (ctDNA) is readily detectable in patients with CLL. Importantly, ctDNA does not simply mirror the genomic information contained within circulating malignant lymphocytes but instead parallels changes across different disease compartm ...[more]