Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children.

ABSTRACT:

Background

Allergic and nonallergic asthma severity in children can be affected by microbial exposures.

Objective

We sought to examine associations between exposures to household microbes and childhood asthma severity stratified by atopic status.

Methods

Participants (n = 196) were selected from a cohort of asthmatic children in Connecticut and Massachusetts. Children were grouped according to asthma severity (mild with no or minimal symptoms and medication or moderate to severe persistent) and atopic status (determined by serum IgE levels). Microbial community structure and concentrations in house dust were determined by using next-generation DNA sequencing and quantitative PCR. Logistic regression was used to explore associations between asthma severity and exposure

SUBMITTER: Dannemiller KC 

PROVIDER: S-EPMC5357886 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature