Ontology highlight
ABSTRACT:
SUBMITTER: Fourgeaud L
PROVIDER: S-EPMC5358512 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nature 20160406 7598
Microglia are damage sensors for the central nervous system (CNS), and the phagocytes responsible for routine non-inflammatory clearance of dead brain cells. Here we show that the TAM receptor tyrosine kinases Mer and Axl regulate these microglial functions. We find that adult mice deficient in microglial Mer and Axl exhibit a marked accumulation of apoptotic cells specifically in neurogenic regions of the CNS, and that microglial phagocytosis of the apoptotic cells generated during adult neurog ...[more]