The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man.

ABSTRACT: The intestine exerts a considerable influence over urinary oxalate in two ways, through the absorption of dietary oxalate and by serving as an adaptive extra-renal pathway for elimination of this waste metabolite. Knowledge of the mechanisms responsible for oxalate absorption and secretion by the intestine therefore have significant implications for understanding the etiology of hyperoxaluria, as well as offering potential targets for future treatment strategies for calcium oxalate kidney stone disease. In this review, we present the recent developments and advances in this area over the past 10 years, and put to the test some of the new ideas that have emerged during this time, using human and mouse models. A key focus for our discussion are the membrane-bound anion exchangers, belonging

SUBMITTER: Whittamore JM 

PROVIDER: S-EPMC5358548 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature