Candidate gene analyses of 3-dimensional dentoalveolar phenotypes in subjects with malocclusion.

ABSTRACT:

Introduction

Genetic studies of malocclusion etiology have identified 4 deleterious mutations in genes DUSP6,ARHGAP21, FGF23, and ADAMTS1 in familial Class III cases. Although these variants may have large impacts on Class III phenotypic expression, their low frequency (<1%) makes them unlikely to explain most malocclusions. Thus, much of the genetic variation underlying the dentofacial phenotypic variation associated with malocclusion remains unknown. In this study, we evaluated associations between common genetic variations in craniofacial candidate genes and 3-dimensional dentoalveolar phenotypes in patients with malocclusion.

Methods

Pretreatment dental casts or cone-beam computed tomographic images from 300 healthy subjects were digitized with 48 landmarks. The 3-dimens

SUBMITTER: Weaver CA 

PROVIDER: S-EPMC5358674 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature