Alterations in splenic function and gene expression in mice with depressive-like behavior induced by exposure to corticosterone.

ABSTRACT: Depressed patients present with increased cortisol levels and attenuated immune responses. However, little is known about the association between depression and the spleen, as this is the largest peripheral immune organ. In this study, we examined alterations in splenic function and gene expression in mice with depressive-like behavior, well as the expression of certain proteins in related pathways. A mouse model of depression was established with the use of corticosterone. Splenic function and histopathology were assessed using Wright and H&E staining. The Agilent Whole Mouse Genome Oligo Microarray containing >41,174 transcript probes was used to measure the levels of gene-expression in the spleens from control and model mice, and the levels of certain proteins associated with depression

SUBMITTER: Zhan H 

PROVIDER: S-EPMC5358716 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature