The establishment and characterization of the first canine hepatocellular carcinoma cell line, which resembles human oncogenic expression patterns.

ABSTRACT: BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most worldwide frequent primary carcinomas resulting in the death of many cirrhotic patients. Unfortunately, the molecular mechanisms of this cancer are not well understood; therefore, we need a good model system to study HCC. The dog is recognized as a promising model for human medical research, namely compared with rodents. The objective of this study was to establish and characterize a spontaneous canine tumor cell line as a potential model for studies on HCC. RESULTS: Histomorphological, biochemical, molecular biological and quantitative assays were performed to characterize the canine HCC cell line that originated from a dog with a spontaneous liver tumor. Morphological investigations provided strong evidence for the hepatocytic

SUBMITTER: Boomkens SY 

PROVIDER: S-EPMC535891 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature