Evolution and Epidemiology of Multidrug-Resistant <i>Klebsiella pneumoniae</i> in the United Kingdom and Ireland.

ABSTRACT: Klebsiella pneumoniae is a human commensal and opportunistic pathogen that has become a leading causative agent of hospital-based infections over the past few decades. The emergence and global expansion of hypervirulent and multidrug-resistant (MDR) clones of K. pneumoniae have been increasingly reported in community-acquired and nosocomial infections. Despite this, the population genomics and epidemiology of MDR K. pneumoniae at the national level are still poorly understood. To obtain insights into these, we analyzed a systematic large-scale collection of invasive MDR K. pneumoniae isolates from hospitals across the United Kingdom and Ireland. Using whole-genome phylogenetic analysis, we placed these in the context of previously sequenced K. pneumoniae

SUBMITTER: Moradigaravand D 

PROVIDER: S-EPMC5358916 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature